Ms. Kanker is the mother of The Kanker Sisters. She is often mentioned in the show.
It's known that she dislikes men and is bad-tempered.
There isn't much known about the Kankers' fathers; except that each Kanker has a seperate father who go by the name Butch, Bubba and Rod and that none of them are around anymore. There are a few possessions they left behind, like their bathrobes and a bucket May claimed belonged to her father.
The Kankers often quote or bring back comments their mother once made.
From Don't Rain On My Ed:
"Mom was wrong. Men do amount to a pile of dirt."
From A Twist of Ed:
"Mom was right, throw a man a bone and he'll mess up the carpet."